Solitary pulmonary metastasis from lung cancer harboring EML4-ALK after a 15-year disease-free interval.
Lung Cancer
; 80(1): 99-101, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23279872
ABSTRACT
It is often difficult to differentiate metachronous primary lung cancers from local pulmonary recurrences when the histopathological findings are similar. A 43-year-old man underwent right upper lobectomy with lymph node dissection for primary lung adenocarcinoma (p-T2aN0M0, stage IB). Fifteen years later, he developed a lung nodule in his right middle lobe. The tumor was preoperatively thought to be a metachronous second primary lung adenocarcinoma, and was surgically resected. Histopathological findings for both tumors were of poorly differentiated adenocarcinoma with mucus production. Both tumors also harbored the EML4 (echinoderm microtubule-associated protein-like 4)-ALK (anaplastic lymphoma kinase) fusion gene (variant 3a+b). Based on this molecular finding, the pulmonary nodule was considered to be a recurrence after very long latent period.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenocarcinoma
/
Oncogene Proteins, Fusion
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Lung
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Lung Neoplasms
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Neoplasm Recurrence, Local
Type of study:
Diagnostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Lung Cancer
Journal subject:
NEOPLASIAS
Year:
2013
Document type:
Article
Affiliation country: