[WNT-ß-catenin signaling pathway and its relationship with cancer]. / La vía de señalización Wnt-ß-catenina y su relación con cáncer.
Cir Cir
; 80(4): 389-98, 2012.
Article
in Es
| MEDLINE
| ID: mdl-23374390
ABSTRACT
The Wnt-ß-catenin signalling pathway plays a crucial role in the regulation, differentiation, proliferation and cellular death processes; consequently, alterations in this pathway are involved in numerous abnormalities of development, growth and homeostasis in animal organisms. Wnt proteins include a numerous family of secretion glycoproteins which join to Frizzled receptors and Low Density Lipoprotein Receptor-related Protein, in order to stabilize the critical ß-catenin protein, and to initiate an intricate signaling cascade, which is related to multiple nucleocytoplasmatic processes. Alterations in the canonical Wnt-ß-catenin signaling pathway have been associated with variations in a number of proteins participating in this route, or with activation / inactivation of oncogenes and tumor suppressor genes, which explain different processes of tumorigenesis, in addition to a number of malformations and human diseases. This review describes the relations between the Wnt-ß-catenin signaling pathway with different neoplasic processes, as well as its application in the diagnosis and prognosis of cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wnt Signaling Pathway
/
Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Es
Journal:
Cir Cir
Year:
2012
Document type:
Article