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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
Vasbinder, Melissa M; Aquila, Brian; Augustin, Martin; Chen, Huawei; Cheung, Tony; Cook, Donald; Drew, Lisa; Fauber, Benjamin P; Glossop, Steve; Grondine, Michael; Hennessy, Edward; Johannes, Jeffrey; Lee, Stephen; Lyne, Paul; Mörtl, Mario; Omer, Charles; Palakurthi, Sangeetha; Pontz, Timothy; Read, Jon; Sha, Li; Shen, Minhui; Steinbacher, Stefan; Wang, Haixia; Wu, Allan; Ye, Minwei.
Affiliation
  • Vasbinder MM; Oncology iMED, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States. melissa.vasbinder@astrazeneca.com
J Med Chem ; 56(5): 1996-2015, 2013 Mar 14.
Article in En | MEDLINE | ID: mdl-23398453
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Country of publication: