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ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
Hilpert, Hans; Guba, Wolfgang; Woltering, Thomas J; Wostl, Wolfgang; Pinard, Emmanuel; Mauser, Harald; Mayweg, Alexander V; Rogers-Evans, Mark; Humm, Roland; Krummenacher, Daniela; Muser, Thorsten; Schnider, Christian; Jacobsen, Helmut; Ozmen, Laurence; Bergadano, Alessandra; Banner, David W; Hochstrasser, Remo; Kuglstatter, Andreas; David-Pierson, Pascale; Fischer, Holger; Polara, Alessandra; Narquizian, Robert.
Affiliation
  • Hilpert H; Discovery Chemistry, Pharma Research & Early Development, Grenzacherstrasse 124, Basel CH-4070, Switzerland. hans.hilpert@roche.com
J Med Chem ; 56(10): 3980-95, 2013 May 23.
Article in En | MEDLINE | ID: mdl-23590342
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartic Acid Endopeptidases / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Alzheimer Disease Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartic Acid Endopeptidases / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Alzheimer Disease Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Country of publication: