A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.
Case Rep Oncol Med
; 2013: 270362, 2013.
Article
in En
| MEDLINE
| ID: mdl-23653877
ABSTRACT
We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.
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1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Case Rep Oncol Med
Year:
2013
Document type:
Article
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