Successful treatment of class IV+V lupus nephritis with combination therapy of high-dose corticosteroids, tacrolimus and intravenous cyclophosphamide.
Intern Med
; 52(10): 1125-30, 2013.
Article
in En
| MEDLINE
| ID: mdl-23676603
ABSTRACT
A substantial number of patients with lupus nephritis (LN) are refractory to conventional glucocorticoid (GC) treatment. Although many of these patients respond to immunosuppressive drugs such as intravenous cyclophosphamide (IVCY), azathioprine (AZA), mizoribine, tacrolimus, cyclosporine A (CSA) and mycofenolate mofetil (MMF), some remain refractory to such therapies. Recent studies of multi-target therapies have reported effective outcomes for immunosuppression following renal transplantation and refractory LN when therapy consists of two or more immunosuppressive drugs with different mechanisms of action. We herein report a case of LN unresponsive to IVCY that was successfully treated with the addition of tacrolimus and discuss the usefulness of multi-target therapy for LN.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lupus Nephritis
/
Prednisolone
/
Tacrolimus
/
Cyclophosphamide
/
Immunosuppressive Agents
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
Intern Med
Journal subject:
MEDICINA INTERNA
Year:
2013
Document type:
Article
Affiliation country: