Long-term follow-up study of gastroduodenal lesions after radioembolization of hepatic tumors.
World J Gastroenterol
; 19(19): 2935-40, 2013 May 21.
Article
in En
| MEDLINE
| ID: mdl-23704826
ABSTRACT
AIM:
To evaluate the long-term natural history of the gastroduodenal lesions secondary to extrahepatic embolization with Ytrium 90 (9°Y) spheres.METHODS:
From September 2003 to January 2012, 379 procedures of liver radioembolization (RE) using resin microspheres loaded with 9°Y were performed in our center. We have retrospectively compiled the data from 379 RE procedures performed in our center. We report a comprehensive clinical, analytical, endoscopic and histologic long-term follow-up of a series of patients who developed gastroduodenal lesions after the treatment.RESULTS:
Six patients (1.5%) developed gastrointestinal symptoms and had gastrointestinal lesions as shown by upper endoscopy in the next 12 wk after RE. The mean time between RE and the appearance of symptoms was 5 wk. Only one patient required endoscopic and surgical treatment. The incidence of gastrointestinal ulcerations was 3.75% (3/80) when only planar images were used for the pre-treatment evaluation. It was reduced to 1% (3/299) when single-photon emission computed tomography (SPECT) images were also performed. The symptoms that lasted for a longer time were nausea and vomiting, until 25 mo after the treatment.CONCLUSION:
All patients were free from severe symptoms at the end of follow-up. The routine use of SPECT has decreased the incidence of gastrointestinal lesions due to unintended deployment of 9°Y particles.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Injuries
/
Stomach Ulcer
/
Yttrium Radioisotopes
/
Chemoembolization, Therapeutic
/
Radiopharmaceuticals
/
Duodenal Ulcer
/
Liver Neoplasms
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
World J Gastroenterol
Journal subject:
GASTROENTEROLOGIA
Year:
2013
Document type:
Article
Affiliation country: