Top-down chemoenzymatic approach to a high-mannose-type glycan library: synthesis of a common precursor and its enzymatic trimming.
Angew Chem Int Ed Engl
; 52(29): 7426-31, 2013 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-23740650
ABSTRACT
From the stacks A novel method for construction of a high-mannose-type glycan library by systematic enzymatic trimming of a single synthetic Man9-based precursor was developed. Efficient chemical synthesis of the tetradecasaccharide common precursor and orthogonal enzymatic trimming to obtain all M(8-9) and G(1)M(8-9) derivatives was demonstrated. G = glucose, M = mannose.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polysaccharides
/
Mannose
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2013
Document type:
Article
Affiliation country: