Synthesis of a novel water-soluble zinc phthalocyanine and its CT DNA-damaging studies.
Spectrochim Acta A Mol Biomol Spectrosc
; 115: 445-51, 2013 Nov.
Article
in En
| MEDLINE
| ID: mdl-23867647
ABSTRACT
A novel 3-(4-methoxybenzylamino) propanoic acid substituted water-soluble zinc phthalocyanine (CNPcZn) was synthesized. The interaction between CNPcZn with calf thymus DNA (CT DNA) was studied using spectroscopic methods. The studies indicated that CNPcZn has strong affinity to CT DNA, and furthermore, CNZnPc showed excellent photodamaging activity to CT DNA. Above results indicated that such CNPcZn has great potential to be used as an effective photosensitizer in the field of photodynamic therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
DNA Damage
/
DNA
/
Water
/
Indoles
Limits:
Animals
Language:
En
Journal:
Spectrochim Acta A Mol Biomol Spectrosc
Journal subject:
BIOLOGIA MOLECULAR
Year:
2013
Document type:
Article