Adipocyte protein modification by Krebs cycle intermediates and fumarate ester-derived succination.
Amino Acids
; 45(5): 1243-7, 2013 Nov.
Article
in En
| MEDLINE
| ID: mdl-23892396
ABSTRACT
Protein succination, the non-enzymatic modification of cysteine residues by fumarate, is distinguishable from succinylation, an enzymatic reaction forming an amide bond between lysine residues and succinyl-CoA. Treatment of adipocytes with 30 mM glucose significantly increases protein succination with only a small change in succinylation. Protein succination may be significantly increased intracellularly after treatment with fumaric acid esters, however, the ester must be removed by saponification to permit 2SC-antibody detection of the fumarate adduct.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
/
Citric Acid Cycle
/
Adipocytes
/
Fumarates
Limits:
Animals
Language:
En
Journal:
Amino Acids
Journal subject:
BIOQUIMICA
Year:
2013
Document type:
Article
Affiliation country: