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Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.
Cai, Chaozhong; McComsey, Dave F; Hou, Cuifen; O'Neill, John C; Opas, Evan; McKenney, Sandra; Johnson, Dana; Sui, Zhihua.
Affiliation
  • Cai C; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA. Electronic address: ccai@its.jnj.com.
  • McComsey DF; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
  • Hou C; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
  • O'Neill JC; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
  • Opas E; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
  • McKenney S; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
  • Johnson D; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
  • Sui Z; Janssen Research and Development, L.L.C. Welsh & McKean Roads, Spring House, Box 776, PA 19477, USA.
Bioorg Med Chem Lett ; 24(4): 1239-42, 2014 Feb 15.
Article in En | MEDLINE | ID: mdl-23916257
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cyclopentanes / Receptors, CCR2 / Drug Discovery Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cyclopentanes / Receptors, CCR2 / Drug Discovery Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article