Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
Rhinology
; 51(3): 222-30, 2013 Sep.
Article
in En
| MEDLINE
| ID: mdl-23943728
ABSTRACT
BACKGROUND:
The paranasal sinuses can be a bacterial reservoir for pulmonary infections in patients with cystic fibrosis (CF)METHODOLOGY:
In this prospective, non-randomised, uncontrolled, intervention cohort study, the clinical effect of sinus surgery followed by two weeks` intravenous antibiotics, 6 months` antibiotic nasal irrigations was assessed in 106 CF patients.RESULTS:
One year after sinus surgery, the prevalence of intermittently colonised patients had decreased by 38%, while the prevalence of non-colonised patients had increased by 150%. The frequency of pulmonary samples with CF pathogens was reduced after surgery. Specific IgG against P. aeruginosa decreased after six months. Additionally, the self reported symptoms of chronic rhinosinusitis and quality of life improved.CONCLUSION:
Combined sinus surgery and postoperative systemic and topical antibiotic treatment significantly reduced the frequency of pulmonary samples positive for CF pathogens in the first year after sinus surgery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paranasal Sinuses
/
Pseudomonas Infections
/
Sinusitis
/
Rhinitis
/
Gram-Negative Bacterial Infections
/
Burkholderia Infections
/
Cystic Fibrosis
/
Anti-Bacterial Agents
Type of study:
Clinical_trials
/
Observational_studies
Aspects:
Patient_preference
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Rhinology
Year:
2013
Document type:
Article
Affiliation country: