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Infusion of foam sclerosants results in a distance-dependent procoagulant activity, haemoconcentration and elevation of D-dimer levels.
Connor, D E; Joseph, J E; Exner, T; Ma, D D F; Parsi, K.
Affiliation
  • Connor DE; Dermatology, Phlebology and Fluid Mechanics Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia Haematology Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia University of New South Wales, Sydney, Australia.
  • Joseph JE; Haematology Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia University of New South Wales, Sydney, Australia.
  • Exner T; Haematex Research, Hornsby, Australia.
  • Ma DD; Haematology Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia University of New South Wales, Sydney, Australia.
  • Parsi K; Dermatology, Phlebology and Fluid Mechanics Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia Haematology Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia University of New South Wales, Sydney, Australia kparsi@stvincents
Phlebology ; 29(10): 677-87, 2014 Dec.
Article in En | MEDLINE | ID: mdl-24002013
ABSTRACT

OBJECTIVE:

To investigate the biological effects of foam sclerotherapy in vivo. MATERIALS AND

METHODS:

Ultrasound-guided sclerotherapy was performed using a 3% sodium tetradecyl sulphate or polidocanol. A total of 15 mL of foam was injected. Samples were collected from antecubital veins, target saphenous veins and the adjoining deep veins before, immediately after and 1 hour after the procedure. Saphenous vein samples were also taken sequentially at set 15 cm intervals. Clotting times, D-dimer, cell counts and biochemical parameters were measured. D-dimer levels were repeated one week later.

RESULTS:

Forty procedures were performed. Systemic clotting times were not affected by the procedure. Injection of 0.5 mL of foam 5 cm away from the relevant junctions resulted in procoagulant activity in the adjoining deep veins (sodium tetradecyl sulphate) and the target saphenous veins (sodium tetradecyl sulphate and polidocanol). The procoagulant effect in the target veins reached a peak at 15 cm but normalised at 45 cm. D-dimer levels were significantly increased 1 hour after treatment with either agent and remained elevated one week later. Sodium tetradecyl sulphate and to a lesser degree polidocanol induced biochemical changes consistent with haemoconcentration.

CONCLUSION:

Infusion of foam sclerosants results in a distance-dependent procoagulant activity in the exposed vessels. Foam sclerotherapy results in haemoconcentration and elevation of D-dimer.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Sclerosing Solutions / Sodium Tetradecyl Sulfate / Fibrin Fibrinogen Degradation Products / Sclerotherapy / Thrombophilia Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Phlebology Journal subject: ANGIOLOGIA Year: 2014 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Sclerosing Solutions / Sodium Tetradecyl Sulfate / Fibrin Fibrinogen Degradation Products / Sclerotherapy / Thrombophilia Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Phlebology Journal subject: ANGIOLOGIA Year: 2014 Document type: Article Affiliation country: