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Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.
Mirguet, Olivier; Gosmini, Romain; Toum, Jérôme; Clément, Catherine A; Barnathan, Mélanie; Brusq, Jean-Marie; Mordaunt, Jacqueline E; Grimes, Richard M; Crowe, Miriam; Pineau, Olivier; Ajakane, Myriam; Daugan, Alain; Jeffrey, Phillip; Cutler, Leanne; Haynes, Andrea C; Smithers, Nicholas N; Chung, Chun-wa; Bamborough, Paul; Uings, Iain J; Lewis, Antonia; Witherington, Jason; Parr, Nigel; Prinjha, Rab K; Nicodème, Edwige.
Affiliation
  • Mirguet O; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 Avenue du Québec, 91140 Villebon-sur-Yvette, France.
J Med Chem ; 56(19): 7501-15, 2013 Oct 10.
Article in En | MEDLINE | ID: mdl-24015967
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Benzodiazepines / Nuclear Proteins / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Benzodiazepines / Nuclear Proteins / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: