Long-term experience with reduced planning target volume margins and intensity-modulated radiotherapy with daily image-guidance for head and neck cancer.
Head Neck
; 36(12): 1766-72, 2014 Dec.
Article
in En
| MEDLINE
| ID: mdl-24174221
ABSTRACT
BACKGROUND:
The purpose of this study was to compare outcomes among patients treated by intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for head and neck cancer according to the margins used to expand the clinical target volume (CTV) to create a planning target volume (PTV).METHODS:
Three hundred sixty-seven consecutive patients were treated with IMRT for squamous cell carcinoma of the head and neck. The first 103 patients were treated with 5-mm CTV-to-PTV margins. The subsequent 264 patients were treated using reduced (3 mm) margins.RESULTS:
The 3-year locoregional control for patients treated using 5-mm and 3-mm CTV-to-PTV margins, respectively, was 78% and 80% (p = .75). The incidence of gastrostomy-tube dependence at 1 year was 10% and 3%, respectively (p = .001). The incidence of posttreatment esophageal stricture was 14% and 7%, respectively (p = .01).CONCLUSION:
The use of reduced (3 mm) CTV-to-PTV margins was associated with reduced late toxicity while maintaining locoregional control.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiotherapy Planning, Computer-Assisted
/
Carcinoma, Squamous Cell
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Radiotherapy, Intensity-Modulated
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Radiotherapy, Image-Guided
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Head and Neck Neoplasms
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Neoplasm Recurrence, Local
Type of study:
Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
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Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2014
Document type:
Article