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Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism.
Leivers, Martin; Miller, John F; Chan, Stephanie A; Lauchli, Ryan; Liehr, Sebastian; Mo, Wenyan; Ton, Tony; Turner, Elizabeth M; Youngman, Michael; Falls, J Greg; Long, Susan; Mathis, Amanda; Walker, Jill.
Affiliation
  • Leivers M; GlaxoSmithKline Research & Development , 5 Moore Drive, Research Triangle Park, North Carolina 27709, United States.
J Med Chem ; 57(5): 1964-75, 2014 Mar 13.
Article in En | MEDLINE | ID: mdl-24224729
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyridazines / Viral Nonstructural Proteins / Hepacivirus / Enzyme Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyridazines / Viral Nonstructural Proteins / Hepacivirus / Enzyme Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Country of publication: