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Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.
Hong, Susie N; Gona, Philimon; Fontes, Joao D; Oyama, Noriko; Chan, Raymond H; Kenchaiah, Satish; Tsao, Connie W; Yeon, Susan B; Schnabel, Renate B; Keaney, John F; O'Donnell, Christopher J; Benjamin, Emelia J; Manning, Warren J.
Affiliation
  • Hong SN; Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
J Am Heart Assoc ; 2(6): e000307, 2013 Nov 15.
Article in En | MEDLINE | ID: mdl-24242683
ABSTRACT

BACKGROUND:

The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort. METHODS AND

RESULTS:

We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09).

CONCLUSIONS:

In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.
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Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta, Abdominal / Aorta, Thoracic / Aortic Diseases / Magnetic Resonance Imaging / Inflammation Mediators / Atherosclerosis Type of study: Etiology_studies / Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do norte Language: En Journal: J Am Heart Assoc Year: 2013 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta, Abdominal / Aorta, Thoracic / Aortic Diseases / Magnetic Resonance Imaging / Inflammation Mediators / Atherosclerosis Type of study: Etiology_studies / Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do norte Language: En Journal: J Am Heart Assoc Year: 2013 Document type: Article Affiliation country: