Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene.
Genet Mol Res
; 12(4): 5842-50, 2013 Nov 22.
Article
in En
| MEDLINE
| ID: mdl-24301953
ABSTRACT
ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophils dropped significantly; there was also a significant decrease in MDR1 and MRP1 gene expression. A significant reduction in expression of P-gp was found; however, there was no significant decrease in the expression of MRP1 and NF-κB p65. We conclude that regulation of membrane efflux transport protein could be a factor in benzene hematotoxicity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzene
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Monocytes
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Multidrug Resistance-Associated Proteins
/
Transcription Factor RelA
Limits:
Animals
Language:
En
Journal:
Genet Mol Res
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA
Year:
2013
Document type:
Article
Affiliation country: