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Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea.
Zhou, Wei; Li, Jiao; E, Heng-Chao; Liu, Bao-Shu; Tang, Hua; Gerwick, William H; Hua, Hui-Ming; Zhang, Wen.
Affiliation
  • Zhou W; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. zhouwei_0728@163.com.
  • Li J; Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. lijiao_2012@126.com.
  • E HC; Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. ehengchao@126.com.
  • Liu BS; Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. liubaoshu@126.com.
  • Tang H; Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. tanghua0309@126.com.
  • Gerwick WH; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA. wgerwick@ucsd.edu.
  • Hua HM; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. zhouwei_0728@163.com.
  • Zhang W; Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. wenzhang1968@163.com.
Mar Drugs ; 12(2): 589-600, 2014 Jan 27.
Article in En | MEDLINE | ID: mdl-24473165
ABSTRACT
Four new briarane diterpenoids, junceellolides M-P (1-4), were isolated together with seven known analogs (5-11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1-3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthozoa / Diterpenes / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2014 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthozoa / Diterpenes / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2014 Document type: Article Affiliation country: