[Goodpasture's disease: a case series]. / La Malattia di Goodpasture: l'esperienza di un singolo centro.
G Ital Nefrol
; 31(1)2014.
Article
in It
| MEDLINE
| ID: mdl-24671842
ABSTRACT
Goodpasture's disease (GD) is an uncommon and severe autoimmune disorder caused by circulating autoantibodies directed against the glomerular basement membrane cross-reacting with the alveolar basement membrane. GD is clinically characterized by rapidly progressive glomerulonephritis, often associated with pulmonary hemorrhage representing a nephrological emergency. We present the clinical features of 9 cases, diagnosed in 1997-2012, in our Renal Unit. Contrary to previous reports, we found a predominance of GD in females and we observed unusual clinical patterns, such as the association with renal vein thrombosis in a pregnant patient, thrombosis of the pulmonary arteries and a late isolated recurrence of alveolitis. In dialysis-dependent patients, renal transplantation can represent an available treatment option.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anti-Glomerular Basement Membrane Disease
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
G Ital Nefrol
Journal subject:
NEFROLOGIA
Year:
2014
Document type:
Article