Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients.
Neoplasma
; 61(4): 468-75, 2014.
Article
in En
| MEDLINE
| ID: mdl-24712846
ABSTRACT
The inhibitor of growth 2 (ING2) is a member of lNG family, involved in cell cycle regulation, DNA repair, apoptosis and senescence, and participating in chromatin remodeling and transcriptional regulation by histone modification. Recent researches suggest ING2 plays roles in carcinogenesis both as tumor suppressor gene and ongocene depending on tumor types and cell status. Here, we investigated the status of ING2 in a series of 64 Chinese non-small cell lung cancer (NSCLC)patients using immunohistochemistry (IHC) and confirmed the results with Western blotting. RT-PCR results revealed the expression level of ING2 was consistent with mRNA level. The IHC results showed that ING2 protein expression was significantly decreased in NSCLC samples compared with normal lung tissues (P
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Biomarkers, Tumor
/
Receptors, Cytoplasmic and Nuclear
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Carcinoma, Non-Small-Cell Lung
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Homeodomain Proteins
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Tumor Suppressor Proteins
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Lung Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Neoplasma
Year:
2014
Document type:
Article