Pharyngeal spasticity due to dantrolene.
J Clin Pharm Ther
; 39(4): 449-51, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-24725261
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene. CASESUMMARY:
A 12-year-old male received dantrolene 3 mg/kg/day in adjunct to baclofen 2 mg/kg/day, to improve spasticity. After 5 days of full-dose dantrolene, his dysphagia worsened and he developed pharyngeal spasm. Dantrolene was suspected for an adverse reaction and removed. The patient subsequently improved. WHAT IS NEW ANDCONCLUSION:
Causality analysis determined a probable relationship between dantrolene and pharyngeal spasm. This may be due to direct muscle contraction by dantrolene, an effect seen previously in vitro.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharyngeal Diseases
/
Dantrolene
/
Muscle Relaxants, Central
/
Muscle Spasticity
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
J Clin Pharm Ther
Journal subject:
FARMACIA
/
TERAPEUTICA
Year:
2014
Document type:
Article
Affiliation country: