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Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
Xie, Han; Hanai, Jun-Ichi; Ren, Jian-Guo; Kats, Lev; Burgess, Kerri; Bhargava, Parul; Signoretti, Sabina; Billiard, Julia; Duffy, Kevin J; Grant, Aaron; Wang, Xiaoen; Lorkiewicz, Pawel K; Schatzman, Sabrina; Bousamra, Michael; Lane, Andrew N; Higashi, Richard M; Fan, Teresa W M; Pandolfi, Pier Paolo; Sukhatme, Vikas P; Seth, Pankaj.
Affiliation
  • Xie H; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth
  • Hanai J; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth
  • Ren JG; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth
  • Kats L; Division of Genetics, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  • Burgess K; Division of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  • Bhargava P; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  • Signoretti S; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
  • Billiard J; Cancer Metabolism DPU, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Duffy KJ; Cancer Metabolism DPU, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Grant A; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  • Wang X; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  • Lorkiewicz PK; Center for Regulatory and Environmental Analytical Metabolomics.
  • Schatzman S; Center for Regulatory and Environmental Analytical Metabolomics.
  • Bousamra M; Department of Surgery, University of Louisville, Louisville, KY 40208, USA.
  • Lane AN; Center for Regulatory and Environmental Analytical Metabolomics.
  • Higashi RM; Center for Regulatory and Environmental Analytical Metabolomics.
  • Fan TW; Center for Regulatory and Environmental Analytical Metabolomics. Electronic address: teresa.fan@uky.edu.
  • Pandolfi PP; Division of Genetics, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and
  • Sukhatme VP; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Division of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Isra
  • Seth P; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth
Cell Metab ; 19(5): 795-809, 2014 May 06.
Article in En | MEDLINE | ID: mdl-24726384
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Carcinogenesis / L-Lactate Dehydrogenase / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2014 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Carcinogenesis / L-Lactate Dehydrogenase / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2014 Document type: Article