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SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.
Seneci, Pierfausto; Rizzi, Mattia; Ballabio, Luigi; Lecis, Daniele; Conti, Annalisa; Carrara, Claudio; Licandro, Emanuela.
Affiliation
  • Seneci P; Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy. Electronic address: pierfausto.seneci@unimi.it.
  • Rizzi M; Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
  • Ballabio L; Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
  • Lecis D; Fondazione IRCCS Istituto Nazionale dei Tumori, Dipartimento di Oncologia Sperimentale e Medicina Molecolare, Via Amadeo 42, I-20133 Milan, Italy.
  • Conti A; Fondazione IRCCS Istituto Nazionale dei Tumori, Dipartimento di Oncologia Sperimentale e Medicina Molecolare, Via Amadeo 42, I-20133 Milan, Italy.
  • Carrara C; Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
  • Licandro E; Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy. Electronic address: emanuela.licandro@unimi.it.
Bioorg Med Chem Lett ; 24(10): 2374-8, 2014 May 15.
Article in En | MEDLINE | ID: mdl-24736115
ABSTRACT
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dextrans / Mitochondrial Proteins / Intracellular Signaling Peptides and Proteins / Magnetite Nanoparticles / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dextrans / Mitochondrial Proteins / Intracellular Signaling Peptides and Proteins / Magnetite Nanoparticles / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article