ß-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment.
J Cereb Blood Flow Metab
; 34(7): 1169-79, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-24736891
ABSTRACT
Positron emission tomography (PET) studies using [18F]2-fluoro-2-deoxyglucose (FDG) have identified a well-defined pattern of glucose hypometabolism in Alzheimer's disease (AD). The assessment of the metabolic relationship among brain regions has the potential to provide unique information regarding the disease process. Previous studies of metabolic correlation patterns have demonstrated alterations in AD subjects relative to age-matched, healthy control subjects. The objective of this study was to examine the associations between ß-amyloid, apolipoprotein E É4 (APOE É4) genotype, and metabolic correlations patterns in subjects diagnosed with mild cognitive impairment (MCI). Mild cognitive impairment subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were categorized into ß-amyloid-low and ß-amyloid-high groups, based on quantitative analysis of [18F]florbetapir PET scans, and APOE É4 non-carriers and carriers based on genotyping. We generated voxel-wise metabolic correlation strength maps across the entire cerebral cortex for each group, and, subsequently, performed a seed-based analysis. We found that the APOE É4 genotype was closely related to regional glucose hypometabolism, while elevated, fibrillar ß-amyloid burden was associated with specific derangements of the metabolic correlation patterns.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amyloid beta-Peptides
/
Apolipoprotein E4
/
Cognitive Dysfunction
Type of study:
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Cereb Blood Flow Metab
Year:
2014
Document type:
Article
Affiliation country: