Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.
Kidney Int
; 85(5): 1009-11, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24786873
ABSTRACT
The role of the circulating renin-angiotensin system (RAS) in regulating systemic blood pressure and sodium balance is well established. More recently, researchers have turned their focus to the local generation of angiotensin II (Ang II) in specific tissues. Matsusaka et al. revisit the renal RAS and provide evidence that liver-derived angiotensinogen (AGT) is a major determinant of renal Ang II levels in a model of podocyte injury.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Angiotensin II
/
Angiotensinogen
/
Podocytes
/
Kidney Diseases
/
Kidney Tubules, Proximal
/
Liver
Limits:
Animals
Language:
En
Journal:
Kidney Int
Year:
2014
Document type:
Article
Affiliation country: