First report on the antibody verification of HLA-ABC epitopes recorded in the website-based HLA Epitope Registry.
Tissue Antigens
; 83(6): 391-400, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24828056
ABSTRACT
The International Registry of Antibody-Defined HLA Epitopes ( http//www.epregistry.com.br) has been recently established as a tool to understand humoral responses to human leukocyte antigen (HLA) mismatches. These epitopes are defined structurally by three-dimensional molecular modeling and amino acid sequence differences between HLA antigens. So-called eplets represent essential components of HLA epitopes and they are defined by polymorphic residues. A major goal is to identify HLA epitopes that have been verified experimentally with informative antibodies. Our analysis has also included data in many publications. As of 1 November 2013, 95 HLA-ABC antibody-verified epitopes have been recorded, 62 correspond to eplets and 33 are defined by eplets paired with other residue configurations. The Registry is still a work-in-progress and will become a useful resource for HLA professionals interested in histocompatibility testing at the epitope level and investigating antibody responses to HLA mismatches in transplant patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Histocompatibility Testing
/
Genes, MHC Class I
/
Registries
/
Databases, Protein
/
HLA Antigens
/
Isoantibodies
/
Antibodies, Monoclonal
/
Epitopes
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Tissue Antigens
Year:
2014
Document type:
Article
Affiliation country: