CopA3 peptide prevents ultraviolet-induced inhibition of type-I procollagen and induction of matrix metalloproteinase-1 in human skin fibroblasts.
Molecules
; 19(5): 6407-14, 2014 May 20.
Article
in En
| MEDLINE
| ID: mdl-24853614
ABSTRACT
Ultraviolet (UV) exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1) activity. A 9-mer peptide, CopA3 (CopA3) was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 µM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insect Proteins
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Matrix Metalloproteinase 1
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Antimicrobial Cationic Peptides
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Collagen Type I
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Fibroblasts
Language:
En
Journal:
Molecules
Journal subject:
BIOLOGIA
Year:
2014
Document type:
Article