Association of UBQ-8i polymorphism with Alzheimer's disease in Caucasians: a meta-analysis.
Int J Neurosci
; 125(6): 395-401, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25010605
ABSTRACT
BACKGROUND:
Several studies have reported an association between the UBQ-8i (rs12344615) polymorphism of the UBQLN1 gene and risk of Alzheimer's disease (AD), but these findings remain controversial. In this study, a meta-analysis was carried out to investigate the relationship between UBQ-8i polymorphism and AD risk and a possible synergy with apolipoprotein E (APOE)ε4 gene status.METHODS:
Case-control studies were selected from PubMed, Medline and Embase (Ovid) databases. The potential association was evaluated by odds ratios (ORs) with 95% confidence intervals (CIs). Data were analyzed with Stata version 11.0.RESULTS:
A total of 4679 AD cases and 9928 controls were included in the study. There was no evidence of heterogeneity between studies or publication bias in the meta-analysis. There were no significant differences among the examined genetic models. In the analysis stratified by age of onset, a significant association was detected in the late onset AD group under the allele (OR = 1.12, 95% CI 1.01-1.24), heterozygote (OR = 1.15, 95% CI 1.02-1.30) and dominant (OR = 1.13, 95% CI 1.00-1-26) models. However, UBQ-8i polymorphism was not associated with a higher risk for AD among APOEε4 carriers.CONCLUSION:
The results suggest that UBQ-8i polymorphism may contribute to AD susceptibility, but does not synergize with APOEε4 status to increase AD risk.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carrier Proteins
/
Cell Cycle Proteins
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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Alzheimer Disease
Type of study:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limits:
Female
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Humans
/
Male
Language:
En
Journal:
Int J Neurosci
Year:
2015
Document type:
Article
Affiliation country: