Tolerating DNA damage during eukaryotic chromosome replication.
Exp Cell Res
; 329(1): 170-7, 2014 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-25038291
ABSTRACT
In eukaryotes, the evolutionarily conserved RAD6/RAD18 pathway of DNA damage tolerance overcomes unrepaired DNA lesions that interfere with the progression of replication forks, helping to ensure the completion of chromosome replication and the maintenance of genome stability in every cell cycle. This pathway uses two different strategies for damage bypass translesion DNA synthesis, which is carried out by specialized polymerases that can replicate across the lesions, and DNA damage avoidance, a process that relies on a switch to an undamaged-DNA template for synthesis past the lesion. In this review, we summarise the current knowledge on DNA damage tolerance mechanisms mediated by RAD6/RAD18 that are used by eukaryotic cells to cope with DNA lesions during chromosome replication.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Damage
/
Chromosomes
/
DNA Replication
/
Eukaryotic Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Cell Res
Year:
2014
Document type:
Article
Affiliation country: