The effect of testosterone replacement on plasma lipids and apolipoproteins.
Eur J Clin Invest
; 19(5): 438-41, 1989 Oct.
Article
in En
| MEDLINE
| ID: mdl-2511020
ABSTRACT
Ten men with Klinefelter's syndrome were studied to assess the effect of testosterone replacement on plasma lipids and apolipoproteins. Measurements taken before the insertion of a testosterone ester implant were compared with those obtained 1 week and 4 weeks later. Mean plasma testosterone, androstenedione, total cholesterol and calculated LDL-cholesterol increased significantly after 1 and 4 weeks. No significant changes were seen in total plasma concentrations of HDL-cholesterol, HDL-cholesterol subfractions 2 and 3 or in apoplipoproteins A-I, A-II or B. A significant correlation was seen between total cholesterol and plasma oestradiol concentrations (Rs = 0.61; P less than 0.001). A significant negative correlation was seen between the concentrations of total testosterone and total triglyceride (Rs = -0.56; P less than 0.005) but not with the other lipid parameters. Testosterone replacement is associated with slight but potentially adverse changes in plasma cholesterol levels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apolipoproteins
/
Testosterone
/
Lipids
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Eur J Clin Invest
Year:
1989
Document type:
Article
Affiliation country: