Renal distribution of Vasohibin-1 in patients with chronic kidney disease.
Acta Med Okayama
; 68(4): 219-33, 2014.
Article
in En
| MEDLINE
| ID: mdl-25145408
ABSTRACT
Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (rï¼0.48, pï¼0.001) or cortex (rï¼0.64, pï¼0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (rï¼0.34, pï¼0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (rï¼0.44, pï¼0.01) or medulla (rï¼0.63, pï¼0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Cycle Proteins
/
Renal Insufficiency, Chronic
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Med Okayama
Year:
2014
Document type:
Article
Affiliation country: