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Antimycobacterial activity generated by the amide coupling of (-)-fenchone derived aminoalcohol with cinnamic acids and analogues.
Slavchev, Ivaylo; Dobrikov, Georgi M; Valcheva, Violeta; Ugrinova, Iva; Pasheva, Evdokia; Dimitrov, Vladimir.
Affiliation
  • Slavchev I; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, bl. 9, Acad. G. Bonchev str., Sofia 1113, Bulgaria.
  • Dobrikov GM; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, bl. 9, Acad. G. Bonchev str., Sofia 1113, Bulgaria. Electronic address: gmdob@orgchm.bas.bg.
  • Valcheva V; Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, bl. 26, Acad. G. Bonchev str., Sofia 1113, Bulgaria.
  • Ugrinova I; Institute of Molecular Biology 'Roumen Tsanev', Bulgarian Academy of Sciences, bl. 21, Acad. G. Bonchev str., Sofia 1113, Bulgaria.
  • Pasheva E; Institute of Molecular Biology 'Roumen Tsanev', Bulgarian Academy of Sciences, bl. 21, Acad. G. Bonchev str., Sofia 1113, Bulgaria.
  • Dimitrov V; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, bl. 9, Acad. G. Bonchev str., Sofia 1113, Bulgaria.
Bioorg Med Chem Lett ; 24(21): 5030-3, 2014 Nov 01.
Article in En | MEDLINE | ID: mdl-25248685
ABSTRACT
Aminoethyl substituted 2-endo-fenchol prepared from (-)-fenchone was used as scaffold for the synthesis of series of 31 amide structures by N-acylation applying cinnamic acids and analogues. The evaluation of their in vitro activity against Mycobacterium tuberculosis H37Rv showed for some of them promising activity-up to 0.2 µg/ml, combined with relatively low cytotoxicity of the selected active compounds.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cinnamates / Amides / Amino Alcohols / Norbornanes / Antitubercular Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cinnamates / Amides / Amino Alcohols / Norbornanes / Antitubercular Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country: