Uric acid relates to dopamine transporter availability in Parkinson's disease.
Acta Neurol Scand
; 131(2): 127-31, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-25288358
ABSTRACT
BACKGROUND:
Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid (UA) and dopamine transporter (DaT) binding deserve more investigations. AIMS OF THE STUDY We aimed to investigate the relationship between serum UA levels and DaT availability in newly diagnosed, drug-naïve PD patients, by means of semiquantitative [(123) I]FP-CIT-SPECT.METHODS:
We recruited 52 newly diagnosed, drug-naïve PD patients, and performed serum UA dosage and [(123) I]FP-CIT-SPECT.RESULTS:
Pearson's correlation analysis showed that UA levels were significantly higher in patients with higher averaged, ipsilateral and contralateral DaT binding in caudate, putamen, and striatum.CONCLUSIONS:
We showed, for the first time, by regional semiquantitative analysis of DaT binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. This study broadens our knowledge on the importance of UA as a biomarker of PD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Uric Acid
/
Dopamine Plasma Membrane Transport Proteins
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Neurol Scand
Year:
2015
Document type:
Article
Affiliation country:
Publication country:
DENMARK
/
DINAMARCA
/
DK