Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Dennis, Matthew L; Chhabra, Sandeep; Wang, Zhong-Chang; Debono, Aaron; Dolezal, Olan; Newman, Janet; Pitcher, Noel P; Rahmani, Raphael; Cleary, Ben; Barlow, Nicholas; Hattarki, Meghan; Graham, Bim; Peat, Thomas S; Baell, Jonathan B; Swarbrick, James D

Dennis, Matthew L; Chhabra, Sandeep; Wang, Zhong-Chang; Debono, Aaron; Dolezal, Olan; Newman, Janet; Pitcher, Noel P; Rahmani, Raphael; Cleary, Ben; Barlow, Nicholas; Hattarki, Meghan; Graham, Bim; Peat, Thomas S; Baell, Jonathan B; Swarbrick, James D.

Affiliation

Dennis ML; Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.

J Med Chem ; 57(22): 9612-26, 2014 Nov 26.

Article in En | MEDLINE | ID: mdl-25357262

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcus aureus / Diphosphotransferases / Folic Acid / Guanine Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country:

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