Randomized controlled trial on the efficacy of new alcohol-free chlorhexidine mouthrinses after 8 weeks.
Int J Dent Hyg
; 13(2): 110-6, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25382448
ABSTRACT
OBJECTIVES:
To evaluate the efficacy of two alcohol-free antimicrobial mouthrinses in reducing plaque and gingivitis compared to an alcohol-containing rinse and toothbrushing alone.METHODS:
One hundred and sixty healthy volunteers were enrolled in the randomized controlled trial. Participants were randomly and equally assigned to four groups (i) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-containing rinse, positive control); (ii) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-free experimental rinse); (iii) toothbrushing + rinsing (0.06% CHX + 0.03% CPC + 0.025% NaF, alcohol-free experimental rinse); (iv) toothbrushing alone (negative control). At baseline, Quigley-Hein plaque index (QHI), modified proximal plaque index (MPPI), and papillary bleeding index (PBI) were recorded. All subjects brushed their teeth as usual during the study. Additionally, groups 1-3 rinsed twice daily. Eight weeks after baseline, indices were recorded again. anova with Bonferroni adjustment served for statistical analysis.RESULTS:
One hundred and fifty-five participants were included into final analysis (i n = 39, 2 n = 39, 3 n = 37, 4 n = 40). Experimental rinses (ii, iii) reduced QHI and MPPI to a higher extent than the negative control (iv), whereas no significant difference to the positive control was found. QHI (i) 36.6%, (ii) 32.3%, (iii) 36.8%, (iv) 21.6%; MPPI (i) 11.9%, (ii) 12.2%, (iii) 13.6%, (iv) 3.5%. For PBI, no statistically significant difference was found between groups (i) 80.2%, (ii) 77.8%, (iii) 76.5% and (iv) 78.8%.CONCLUSIONS:
With respect to QHI and MPPI, toothbrushing in combination with any rinse was more effective than toothbrushing alone. No statistically significant differences were found between the alcohol-free and the alcohol-containing control rinses.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chlorhexidine
/
Dental Plaque
/
Gingivitis
/
Anti-Infective Agents, Local
/
Mouthwashes
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
Int J Dent Hyg
Journal subject:
ODONTOLOGIA
Year:
2015
Document type:
Article
Affiliation country: