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G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonists reduce the production of proinflammatory cytokines and stabilize the alternative macrophage phenotype.
Högenauer, Klemens; Arista, Luca; Schmiedeberg, Niko; Werner, Gudrun; Jaksche, Herbert; Bouhelal, Rochdi; Nguyen, Deborah G; Bhat, B Ganesh; Raad, Layla; Rauld, Celine; Carballido, José M.
Affiliation
  • Högenauer K; Global Discovery Chemistry, ‡Autoimmunity, Transplantation and Inflammation, and §Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
J Med Chem ; 57(24): 10343-54, 2014 Dec 26.
Article in En | MEDLINE | ID: mdl-25411721
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Tumor Necrosis Factor-alpha / Interleukin-10 / Niacinamide / Interleukin-12 / Receptors, G-Protein-Coupled / Indoles / Inflammation / Macrophages / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Tumor Necrosis Factor-alpha / Interleukin-10 / Niacinamide / Interleukin-12 / Receptors, G-Protein-Coupled / Indoles / Inflammation / Macrophages / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Country of publication: