Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.
RNA Biol
; 11(9): 1105-12, 2014.
Article
in En
| MEDLINE
| ID: mdl-25483045
ABSTRACT
Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs. In this study, we profiled microRNA expression during the transition from neural progenitors to differentiated astrocytes and underscored 2 upregulated microRNAs, miR-23a and miR-125b, that sinergically act to restrain Musashi1 expression, thus creating a regulatory module controlling neural progenitor proliferation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA-Binding Proteins
/
Gene Expression Regulation, Developmental
/
MicroRNAs
/
Cell Proliferation
/
Embryo, Mammalian
/
Neural Stem Cells
/
Nerve Tissue Proteins
Limits:
Animals
Language:
En
Journal:
RNA Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2014
Document type:
Article
Affiliation country: