The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts.
Biochemistry
; 53(48): 7641-9, 2014 Dec 09.
Article
in En
| MEDLINE
| ID: mdl-25488019
ABSTRACT
The contraction of the right ventricle (RV) expels blood into the pulmonary circulation, and the contraction of the left ventricle (LV) pumps blood into the systemic circulation through the aorta. The respective afterloads imposed on the LV and RV by aortic and pulmonary artery pressures create very different mechanical requirements for the two ventricles. Indeed, differences have been observed in the contractile performance between left and right ventricular myocytes in dilated cardiomyopathy, in congestive heart failure, and in energy usage and speed of contraction at light loads in healthy hearts. In spite of these functional differences, it is commonly believed that the right and left ventricular muscles are identical because there were no differences in stress development, twitch duration, work performance, or power among the RV and LV in dogs. This report shows that on a mesoscopic scale [when only a few molecules are studied (here three to six molecules of actin) in ex vivo ventricular myofibrils], the two ventricles in rigor differ in the degree of orientational disorder of actin within in filaments and during contraction in the kinetics of the cross-bridge cycle.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Actins
/
Myosins
/
Heart Ventricles
Limits:
Animals
Language:
En
Journal:
Biochemistry
Year:
2014
Document type:
Article
Affiliation country: