[Preliminary study of a universal vaccine based on the HA2 protein of the H5N1 influenza virus].
Bing Du Xue Bao
; 30(5): 521-8, 2014 Sep.
Article
in Zh
| MEDLINE
| ID: mdl-25562961
ABSTRACT
Fragments encoding amino acids 76-130 in the linear conserved region (LCR) of A/Hubei/1/2010 (H5N1) HA2 was fused to hepatitis B core antigen (HBc) to generate a LCR-HBe virus-like particle (VLP). Results showed that the fusion protein of LCR-HBc was highly expressed in this prokaryotic expression system. The purified LCR-HBc particle stimulated high levels of IgG production in mice with a titer of > 112 800, and provided 50% cross-protection against lethal challenge by H1N1 viruses.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza Vaccines
/
Hemagglutinin Glycoproteins, Influenza Virus
/
Influenza A Virus, H5N1 Subtype
Limits:
Animals
Language:
Zh
Journal:
Bing Du Xue Bao
Journal subject:
VIROLOGIA
Year:
2014
Document type:
Article
Affiliation country: