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Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
Ellis, J Michael; Altman, Michael D; Bass, Alan; Butcher, John W; Byford, Alan J; Donofrio, Anthony; Galloway, Sheila; Haidle, Andrew M; Jewell, James; Kelly, Nancy; Leccese, Erica K; Lee, Sandra; Maddess, Matthew; Miller, J Richard; Moy, Lily Y; Osimboni, Ekundayo; Otte, Ryan D; Reddy, M Vijay; Spencer, Kerrie; Sun, Binyuan; Vincent, Stella H; Ward, Gwendolyn J; Woo, Grace H C; Yang, Chiming; Houshyar, Hani; Northrup, Alan B.
Affiliation
  • Ellis JM; Department of Discovery Chemistry, ‡Department of Process Research, §Department of Immunology, ∥Department of Pharmacology, ⊥Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, #Department of Safety Assessment and Laboratory Animal Resources, and ▽Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
J Med Chem ; 58(4): 1929-39, 2015 Feb 26.
Article in En | MEDLINE | ID: mdl-25625541
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Protein-Tyrosine Kinases / Protein Kinase Inhibitors / Ether-A-Go-Go Potassium Channels / Amides Type of study: Qualitative_research Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Protein-Tyrosine Kinases / Protein Kinase Inhibitors / Ether-A-Go-Go Potassium Channels / Amides Type of study: Qualitative_research Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: