Your browser doesn't support javascript.
loading
Genetic basis of type 2 diabetes--recommendations based on meta-analysis.
Li, J; Gong, Y-P; Li, C-L; Lu, Y-H; Liu, Y; Shao, Y-H.
Affiliation
  • Li J; Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing, China. shaoyh021206@163.com.
Eur Rev Med Pharmacol Sci ; 19(1): 138-48, 2015 Jan.
Article in En | MEDLINE | ID: mdl-25635987
OBJECTIVE: Despite intensive effort to understand the genetic basis of type 2 diabetes, only a few genes responsible for relatively rare monogenic and syndromic subsets of diabetes are known; however, gene(s) responsible for genetic predispositions to common type 2 diabetes are unknown. The current study was obtained a better understanding of the genetic architecture of type 2 diabetes. MATERIALS AND METHODS: Comprehensive literature search was performed and the extracted data was analyzed. The proportion of variance explained by validated genetic factors for a range of metabolic quantitative traits was analyzed. RESULTS: A fully elucidated landscape of type 2 diabetes genetics may well depict perhaps a hundred or more common variants individually with low impact on disease. CONCLUSIONS: Every individual harbors a combination of different risk alleles and only special compilations of these variants in combination with other genetic and non-genetic components will likely lead to disease.
Subject(s)
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 Type of study: Systematic_reviews Limits: Humans Language: En Journal: Eur Rev Med Pharmacol Sci Journal subject: FARMACOLOGIA / TOXICOLOGIA Year: 2015 Document type: Article Affiliation country: Country of publication:
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 Type of study: Systematic_reviews Limits: Humans Language: En Journal: Eur Rev Med Pharmacol Sci Journal subject: FARMACOLOGIA / TOXICOLOGIA Year: 2015 Document type: Article Affiliation country: Country of publication: