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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
Augustin, Ewa; Skwarska, Anna; Weryszko, Anna; Pelikant, Iwona; Sankowska, Ewa; Borowa-Mazgaj, Barbara.
Affiliation
  • Augustin E; Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk 80233, Poland.
  • Skwarska A; Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk 80233, Poland.
  • Weryszko A; Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk 80233, Poland.
  • Pelikant I; Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk 80233, Poland.
  • Sankowska E; Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk 80233, Poland.
  • Borowa-Mazgaj B; Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk 80233, Poland.
Acta Pharmacol Sin ; 36(3): 385-99, 2015 Mar.
Article in En | MEDLINE | ID: mdl-25640477
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Acridines / Leukemia, Myeloid, Acute / Apoptosis / Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / Mutation / Antineoplastic Agents Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Acridines / Leukemia, Myeloid, Acute / Apoptosis / Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / Mutation / Antineoplastic Agents Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: Country of publication: