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Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
Pike, Kurt G; Morris, Jeff; Ruston, Linette; Pass, Sarah L; Greenwood, Ryan; Williams, Emma J; Demeritt, Julie; Culshaw, Janet D; Gill, Kristy; Pass, Martin; Finlay, M Raymond V; Good, Catherine J; Roberts, Craig A; Currie, Gordon S; Blades, Kevin; Eden, Jonathan M; Pearson, Stuart E.
Affiliation
  • Pike KG; Oncology Innovative Medicines, AstraZeneca , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
J Med Chem ; 58(5): 2326-49, 2015 Mar 12.
Article in En | MEDLINE | ID: mdl-25643210
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Thiourea / Hepatocytes / Multiprotein Complexes / Protein Kinase Inhibitors / Drug Discovery / TOR Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Thiourea / Hepatocytes / Multiprotein Complexes / Protein Kinase Inhibitors / Drug Discovery / TOR Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Country of publication: