Cognitive performances and DAT imaging in early Parkinson's disease with mild cognitive impairment: a preliminary study.
Acta Neurol Scand
; 131(5): 275-81, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25644029
ABSTRACT
OBJECTIVES:
Mild cognitive impairment (MCI) is a common feature in Parkinson's disease (PD). We performed an exploratory study to investigate dopaminergic nigrostriatal innervation and its cognitive correlates in early untreated PD patients with MCI as compared to cognitively intact patients. PATIENTS ANDMETHODS:
A consecutive series of 34-de-novo, drug-naïve patients with PD were enrolled. They underwent [123-I] FP-CIT SPECT and comprehensive neuropsychological battery. MCI was identified in 15 of 34 patients with PD.RESULTS:
The two groups did not show any statistically significant difference in age, sex, disease duration, education, lateralization, and H&Y and Hospital Anxiety and Depression Scale scores. Logistic regression analysis showed that UPDRS-III was weakly associated with MCI (P = 0.034). Partial correlation analysis controlling for UPDRS-III and age suggested that in PD patients with MCI reduced V3â³ values in the more affected caudate were correlated with reduced performances in frontal assessment battery, Trail Making Test part B minus Part A and copy task of the Rey-Osterrieth complex figure test. Reduced V3â³ values in the more and less affected putamen were significantly related with reduced performance in frontal assessment battery and in copy task of Rey-Osterrieth complex figure test, respectively. No correlation was found between neuropsychological scores and DAT availability in PD patients without MCI.CONCLUSIONS:
Although preliminary, our results suggest that striatal dopamine depletion may contribute to some cognitive deficit in early never treated PD patients with MCI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Corpus Striatum
/
Dopamine Plasma Membrane Transport Proteins
/
Cognitive Dysfunction
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Neurol Scand
Year:
2015
Document type:
Article
Affiliation country:
Publication country:
DENMARK
/
DINAMARCA
/
DK