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Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Bui, Minna; Hao, Xiaolin; Shin, Youngsook; Cardozo, Mario; He, Xiao; Henne, Kirk; Suchomel, Julia; McCarter, John; McGee, Lawrence R; San Miguel, Tisha; Medina, Julio C; Mohn, Deanna; Tran, Thuy; Wannberg, Sharon; Wong, Jamie; Wong, Simon; Zalameda, Leeanne; Metz, Daniela; Cushing, Timothy D.
Affiliation
  • Bui M; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Hao X; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Shin Y; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Cardozo M; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • He X; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Henne K; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Suchomel J; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • McCarter J; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • McGee LR; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • San Miguel T; Department of Inflammation Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Medina JC; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Mohn D; Department of Inflammation Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Tran T; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Wannberg S; Department of Inflammation Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Wong J; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Wong S; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
  • Zalameda L; Department of Inflammation Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Metz D; Department of Inflammation Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Cushing TD; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States.
Bioorg Med Chem Lett ; 25(5): 1104-9, 2015 Mar 01.
Article in En | MEDLINE | ID: mdl-25666823
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Protein Kinase Inhibitors / Class I Phosphatidylinositol 3-Kinases Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Protein Kinase Inhibitors / Class I Phosphatidylinositol 3-Kinases Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: Country of publication: