New approaches for imaging and therapy of solid cancer.
Q J Nucl Med Mol Imaging
; 59(2): 168-83, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25693421
ABSTRACT
Radionuclide therapy is a systemic treatment that aims to deliver cytotoxic radiation to cancer cells. Due to their properties, antibodies have been considered as suitable agent for the delivery of therapeutic radioisotopes, radioimmunotherapy (RIT). This article gives an overview of new approaches for imaging and therapy of solid cancer with particular attention to strategies to enhance treatment success. Examples of increased antibody uptake by targeting stromal constituent of tumor microenvironment such as fibronectin (FN) an important tumor-associated angiogenesis targeting agent, with specifically designed antibody format will be provided. Strategies oriented to identify patients most likely to benefit from RIT including identification of radiosensitivity profiles, in vivo target identification by teragnostic approach and better prediction of dosimetric estimates would be presents. Combination regimens such as with chemo-radiotherapy and immunotherapy would be also discussed as an approach to enhance RIT success.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Image Enhancement
/
Drug Delivery Systems
/
Radiopharmaceuticals
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Q J Nucl Med Mol Imaging
Journal subject:
MEDICINA NUCLEAR
Year:
2015
Document type:
Article