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Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma.
Phelps, Doris; Bondra, Kathryn; Seum, Star; Chronowski, Christopher; Leasure, Justin; Kurmasheva, Raushan T; Middleton, Steven; Wang, Dian; Mo, Xiaokui; Houghton, Peter J.
Affiliation
  • Phelps D; Center for Childhood Cancer & Blood Diseases, Nationwide Children's Hospital, Columbus, Ohio, 43205.
  • Bondra K; Wexner Medical Center at The Ohio State University, Arthur G. James Comprehensive Cancer Center and Richard L. Solove Research Institute, Columbus, Ohio.
  • Seum S; Wexner Medical Center at The Ohio State University, Arthur G. James Comprehensive Cancer Center and Richard L. Solove Research Institute, Columbus, Ohio.
  • Chronowski C; Wexner Medical Center at The Ohio State University, Arthur G. James Comprehensive Cancer Center and Richard L. Solove Research Institute, Columbus, Ohio.
  • Leasure J; Wexner Medical Center at The Ohio State University, Arthur G. James Comprehensive Cancer Center and Richard L. Solove Research Institute, Columbus, Ohio.
  • Kurmasheva RT; Center for Childhood Cancer & Blood Diseases, Nationwide Children's Hospital, Columbus, Ohio, 43205.
  • Middleton S; Hoffmann-La Roche, Inc., New York.
  • Wang D; Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois.
  • Mo X; Center for Biostatistics, The Ohio State University, Columbus, Ohio.
  • Houghton PJ; Center for Childhood Cancer & Blood Diseases, Nationwide Children's Hospital, Columbus, Ohio, 43205.
Pediatr Blood Cancer ; 62(8): 1345-52, 2015 Aug.
Article in En | MEDLINE | ID: mdl-25832557
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Radiation-Sensitizing Agents / Rhabdomyosarcoma / Apoptosis / Proto-Oncogene Proteins c-mdm2 / Para-Aminobenzoates Type of study: Prognostic_studies Limits: Animals / Child / Child, preschool / Female / Humans Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2015 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Radiation-Sensitizing Agents / Rhabdomyosarcoma / Apoptosis / Proto-Oncogene Proteins c-mdm2 / Para-Aminobenzoates Type of study: Prognostic_studies Limits: Animals / Child / Child, preschool / Female / Humans Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2015 Document type: Article Country of publication: