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Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection.
Ewing, Adam D; Houlahan, Kathleen E; Hu, Yin; Ellrott, Kyle; Caloian, Cristian; Yamaguchi, Takafumi N; Bare, J Christopher; P'ng, Christine; Waggott, Daryl; Sabelnykova, Veronica Y; Kellen, Michael R; Norman, Thea C; Haussler, David; Friend, Stephen H; Stolovitzky, Gustavo; Margolin, Adam A; Stuart, Joshua M; Boutros, Paul C.
Affiliation
  • Ewing AD; 1] Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA. [2] Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.
  • Houlahan KE; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Hu Y; Sage Bionetworks, Seattle, Washington, USA.
  • Ellrott K; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.
  • Caloian C; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Yamaguchi TN; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Bare JC; Sage Bionetworks, Seattle, Washington, USA.
  • P'ng C; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Waggott D; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Sabelnykova VY; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Kellen MR; Sage Bionetworks, Seattle, Washington, USA.
  • Norman TC; Sage Bionetworks, Seattle, Washington, USA.
  • Haussler D; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.
  • Friend SH; Sage Bionetworks, Seattle, Washington, USA.
  • Stolovitzky G; IBM Computational Biology Center, T.J. Watson Research Center, Yorktown Heights, New York, USA.
  • Margolin AA; 1] Sage Bionetworks, Seattle, Washington, USA. [2] Computational Biology Program, Oregon Health &Science University, Portland, Oregon, USA. [3] Department of Biomedical Engineering, Oregon Health &Science University, Portland, Oregon, USA.
  • Stuart JM; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.
  • Boutros PC; 1] Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Pharmacology &Toxicology, University of Toronto, Toronto, Ontario, Canada.
Nat Methods ; 12(7): 623-30, 2015 Jul.
Article in En | MEDLINE | ID: mdl-25984700
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome / Benchmarking / Polymorphism, Single Nucleotide / Crowdsourcing / Neoplasms Type of study: Diagnostic_studies / Guideline Limits: Humans Language: En Journal: Nat Methods Journal subject: TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2015 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome / Benchmarking / Polymorphism, Single Nucleotide / Crowdsourcing / Neoplasms Type of study: Diagnostic_studies / Guideline Limits: Humans Language: En Journal: Nat Methods Journal subject: TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2015 Document type: Article Affiliation country: