Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.
J Magn Reson Imaging
; 42(6): 1759-64, 2015 Dec.
Article
in En
| MEDLINE
| ID: mdl-26012876
ABSTRACT
PURPOSE:
To evaluate between-site agreement of apparent diffusion coefficient (ADC) measurements in preclinical magnetic resonance imaging (MRI) systems. MATERIALS ANDMETHODS:
A miniaturized thermally stable ice-water phantom was devised. ADC (mean and interquartile range) was measured over several days, on 4.7T, 7T, and 9.4T Bruker, Agilent, and Magnex small-animal MRI systems using a common protocol across seven sites. Day-to-day repeatability was expressed as percent variation of mean ADC between acquisitions. Cross-site reproducibility was expressed as 1.96 × standard deviation of percent deviation of ADC values.RESULTS:
ADC measurements were equivalent across all seven sites with a cross-site ADC reproducibility of 6.3%. Mean day-to-day repeatability of ADC measurements was 2.3%, and no site was identified as presenting different measurements than others (analysis of variance [ANOVA] P = 0.02, post-hoc test n.s.). Between-slice ADC variability was negligible and similar between sites (P = 0.15). Mean within-region-of-interest ADC variability was 5.5%, with one site presenting a significantly greater variation than the others (P = 0.0013).CONCLUSION:
Absolute ADC values in preclinical studies are comparable between sites and equipment, provided standardized protocols are employed.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Image Interpretation, Computer-Assisted
/
Image Enhancement
/
Diffusion Magnetic Resonance Imaging
Type of study:
Clinical_trials
/
Evaluation_studies
Country/Region as subject:
America do norte
/
Europa
Language:
En
Journal:
J Magn Reson Imaging
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2015
Document type:
Article
Affiliation country: